Genitourinary medical oncologist Dr. Salomon Tendler examines his patient with a stethoscope.
MSK's Guide To

Prostate Cancer Treatment

Overview of prostate cancer treatment

We know you want excellent treatment results. But not everyone’s goals or priorities are the same. We listen to what matters most to you. Our experts work with you on a care plan that’s best for you.

There are many options for prostate cancer treatment. You may feel overwhelmed as you explore them.  

This guide will help you better understand your options and get ready to talk with your doctors. You’ll have the information you need to make the best decisions for your care together.   

Your care team includes doctors, nurses, and other experts in prostate cancer. MSK’s prostate cancer experts will make a treatment plan just for you.  

Your prostate cancer treatment will target the type and stage of prostate cancer you have. It will be based on the latest research and therapies. During your treatment, you may have a few therapies for the best possible results.  

A care team member wearing surgical protection gear during a robotic prostatectomy.
Surgery

Some people with prostate cancer have surgery to remove cancer that has not spread. The type of surgery depends on the type of prostate cancer you have and its location, size, and stage.   

Urologic surgeon Dr. Jaspreet Sandhu, wearing surgical protection, looks at a monitor.
Radiation therapy

Radiation therapy uses high-energy X-rays to kill cancer cells. We use radiation therapy to treat people for many types of prostate cancer. 

Two MSK care team members during a theranostics procedure, with one of them pressing a button on a machine with a gloved hand.
Systemic therapies

Prostate cancer hormone therapy, theranostics, targeted therapies, chemotherapy (chemo), and immunotherapy are called systemic therapies. They spread throughout the body to treat cancer. 

Urologic surgeon Dr. Jonathan S. Fainberg and nurse practitioner Desiree Robinson are in an exam room.
Focal therapy

Focal therapy uses precise image-guided procedures to treat prostate cancer. Cryoablation, high intensity focused ultrasound (HIFU), and NanoKnife ® are focal therapies. 

Request an appointment

Talk with an MSK Care Advisor. We're here 24 hours a day, 7 days a week. 

How does MSK care for people with prostate cancer?

We care for every person with kindness, warmth, and respect.  

Your care team includes doctors, nurses, and other experts who focus on prostate cancer. They work together using the latest science and research to create your care plan. It will focus on what matters most to you and what’s best for the cancer you have.  

To better understand what is causing the tumor to grow, we may do genetic testing or special molecular imaging studies. These tests could help us offer a targeted treatment for the type of prostate cancer you have.   

Video | 3:32 MSK patients offer helpful tips on becoming a new patient

Newly diagnosed? Hear advice from our patients.

Michael:
You have a diagnosis of cancer, and there's all this fear and there's apprehension and you're nervous and you're scared. You've got surgery in front of you. You've got quality of life issues ahead of you. What I wish I had known was that you can come out the other side of this journey.

Lorena:
When I received the news that I had cancer, it was devastating and I was lost, completely lost. 

Ming:
You are meeting with a lot of different people, so what I would really recommend to patients is just do your best to take notes.

Michael:
Come to the appointment prepared. Come with questions.

Norma:
I had questions about my recovery. I had questions about the possibility of chemo. I was placed on a clinical trial, and I had questions about that.

Michael:
Prior to coming to MSK, my wife and I had been to a variety of different doctors, and we got a lot of different answers and no clear direction. It was the first time that a definitive plan was put in place where I actually had a recommendation of which way to go.

Ming:
My care team consisted of doctors, social workers, nurses.

Michael:
It's not just one doctor you're dealing with. You're dealing with all of MSK and their entire team approach to your care.

Lorena: 
The way they greet me, it was just overwhelming. I was so happy. It was 100% personalized for me.

Norma:
I was told to expect patient-centered care and I kind of felt that from the beginning, from that first day that I walked in.

Ming:
There were even people there just to hang out with me and to kill time. If you need something, ask. And even if it's something small like, “Nothing tastes good,” or “Everything tastes awful and I can't eat any of this,” it's important to tell someone and they can help you address your needs as a patient

Lorena: 
One of the programs that I found helpful was Integrated Medicine. For example, acupuncture. It helped me to calm down; and then after the treatment, it managed the pain. 

Norma:
I immediately used the nutrition program because it was amazing. I used their PT program. I used their Visible Ink program, which is wonderful and it gives you tremendous emotional support.

Lorena: 
Another thing that is very helpful is the MSK Patient Portal. You can set up appointments. You can request prescriptions. You can also use the portal for a telemedicine visit. On the days that you don't have any energy, telemedicine is there for you. There is no difference at all between being seen in person or telemedicine.

Norma:
I never felt that I couldn't call someone, even if it was the doctor's nurse, and just talk.

Ming:
The silver lining from being diagnosed with cancer is I taught myself how to be positive. 

Lorena: 
This experience taught me to live in the moment, and you learn how to live life in a better way. 

At MSK, we take care of the person, not just the cancer. We offer support and resources to help you and your caregivers, during and after treatment.  

Your care plan may include nutrition advice, physical therapy, exercise, and mental health support. Our continued care experts help you manage the side effects of prostate cancer and its treatments.

What makes you feel happiest? Our goal is to treat your cancer and then get you back to the things you enjoy most in life.
Urologic  surgeon  Dr. Bernie Bochner
Will my care team recommend programs that support sexual health?

Cancer and its treatments can have an impact on your sexual health. These changes can affect your physical and emotional health. It may be challenging to have sex or be intimate. MSK has programs to support your sexual health.  

Side effects of prostate cancer treatment can affect your sex life. Our Male Sexual and Reproductive Medicine Program can help you manage:  

  • Desire to have sex 
  • Ejaculation (having an orgasm)  
  • Getting and keeping an erection   
What is urinary incontinence after prostate treatment?

Urinary continence is being able to stop urine (pee) from leaking from your bladder by accident. Leaking urine is called incontinence (in-KON-tih-nents).  

Incontinence can happen right after prostate treatment or later as a long-term side effect. This depends on what type of prostate treatment you had. 

There are a few ways to treat incontinence after prostate treatment. Your MSK continued care team will talk with you about which treatment is right for you. When possible, we’ll recommend treatments that are not invasive, such as pelvic floor muscle (Kegel) exercises. 

Learn more about managing urinary incontinence after prostate treatment

THE MSK DIFFERENCE

MSK’s Wound, Ostomy, and Continence (WOC) care team provides expert care and education. We help manage the most complex wound, ostomy, and continence issues, support recovery after surgery, and improve quality of life. We’re among the few hospitals that offer WOC specialty care at all locations. 

An MSK doctor sits by a computer station in an exam opposite his patient.

Genitourinary medical oncologist Dr. Charles Ryan is on MSK’s team ranked #1 in the nation for urology cancer care by U.S. News & World Report

You’ll get the best possible cancer care at MSK. Your care team has experts in treating the type of prostate cancer you have.
  • If you need surgery: MSK is ranked #1 in the nation for urology cancer care by U.S. News & World Report. When you have prostate cancer, it’s important to find a care team that has lots of experience. 
  •  If you need active surveillance: Prostate cancer monitoring or watchful waiting is a treatment for prostate cancer. 
  • If you need radiation therapy: MSK’s radiation team uses precise methods to deliver strong doses of radiation right to cancer cells. Our experts will choose the best treatments for you. MSK has the country’s busiest brachytherapy program, with a suite just for this internal radiation therapy.  
  • If you need focal therapy: You’ll get image-guided treatment that’s very precise. Our goal is to control the cancer with less harmful side effects.  
  • If you need hormone therapy: We use hormone therapy to slow or stop prostate cancer cells from growing.  
  • If you need theranostic therapy: We use targeted radioactive drugs that travel through your body and find prostate cancer that has spread.  
  • If you need gene-targeted treatment: Some prostate cancers have certain genetic mutations (changes). We use drugs that target those genes for treatment, a method called targeted therapy. 
  • If you need chemotherapy: You’ll have the chemotherapy (chemo) drugs best for you. You also may have access to new drugs through our research studies, also known as clinical trials. 
  • If you need immunotherapy: Prostate cancer rarely is treated with immunotherapy. It may help some people with a certain genetic mutation (change). 
THE MSK DIFFERENCE

Many people prefer to get cancer treatment closer to home. MSK provides excellent cancer care on Long Island and in locations in Westchester County, New Jersey, and New York City. You can meet with your surgeon and have chemotherapy, radiation therapy, and genetic testing.  

Types of prostate cancer treatment

At MSK, all members of your care team will review your case. They’ll talk with you about which treatments are best for you. 

Your care team may offer you a few treatment options. They’re based on your symptoms, any other health issues, and the cancer’s: 

  • Type 
  • Stage, including if it has spread 
  • Location 
  • Genetic information 
  • Grade Group and Gleason score 
  • Risk level 

We assess all these things and then find the best treatment options for you.   

We can treat early-stage low-risk prostate cancers through our Active Surveillance Program.  

Dr. Ehdaie and physician assistant Nicholas Romano talk together at an MSK clinic.

Urologic surgeon Dr. Behfar Ehdaie leads MSK’s active surveillance program for prostate cancer that grows slowly. 

What are the types of prostate cancer surgery?

For some people with prostate cancer, surgery is the best option.  

Your surgeon will talk with you about your options and help you  to get ready. They’ll explain what kind of surgery may be best for you.  

 Surgeons may be able to use minimally invasive methods that: 

  • Do less harm to the body  because it’s done with small incisions (cuts) 
  • Reduce side effects  
  • Improve recovery  

Surgery may sometimes be used along with other therapies. Surgery to remove prostate cancer that’s only in the prostate is called a prostatectomy (PROS-tuh-TEK-toh-mee). A radical prostatectomy removes all of the prostate gland and seminal vesicles.     

Learn more about prostate cancer surgery

THE MSK DIFFERENCE

Many MSK surgeons focus only on prostate cancer. Our prostate surgeons are among the most experienced in the U.S. They’re part of a team ranked #1 in the nation for Urology Cancer Care, 2023 to 2025, by U.S. News & World Report. MSK also ranks among the nation’s top 2 cancer hospitals. 

There are a few reasons why we may recommend surgery, including:    

  • You have early-stage higher-risk prostate cancer that has not spread, and active surveillance is not a good option for you. Our clinical predication tools also can estimate if you have a  long life expectancy. Surgery alone may cure the prostate cancer. 
  • You have a rising prostate-specific antigen (PSA) level after starting treatment with focal therapy. That means there are still prostate cancer cells. 
  • You have a more advanced tumor that can safely be removed with surgery. You also may have other treatments.  

What is radiation therapy for prostate cancer?

Radiation therapy for prostate cancer uses very precise high-energy beams to kill cancer cells. Radiation oncologists are cancer doctors with special training in using radiation to treat cancer. 

MSK’s radiation experts do everything possible to limit healthy tissue’s exposure to radiation. They use the most precise methods to deliver powerful doses of radiation right to the tumor.   

Sometimes we can use methods that lower the number of treatments you’ll need. This can raise the chances of controlling and curing the cancer. 

Radiation therapy aims to control or kill off cancer cells with as few side effects as possible.  

We use radiation therapy:  

  • To treat prostate cancers that have reached the lymph nodes in the pelvis. 
  • To treat prostate cancers that are only in the prostate gland but cannot be removed with surgery. 
  • To treat prostate cancer that surgery could not remove all the way.  
  • To treat prostate cancer in people who decide they do not want surgery.  
  • To relieve symptoms and improve quality of life if the cancer does not respond to surgery. 
THE MSK DIFFERENCE

MSK is a leader in improving ways to kill tumors safely with radiation therapy. We use stereotactic body radiation therapy (SBRT) called MSK Precise®. It lowers the number of treatments you’ll need. MSK Precise lets you get back to your daily life faster because of the shorter treatment schedule.  

What are systemic therapies for prostate cancer?

Systemic therapies are drugs that travel through the body to kill cancer cells. Examples are:  

  • Hormonal therapy 
  • Theranostic treatment 
  • Targeted therapy or immunotherapy for people with certain gene mutations (changes) 
  • Chemotherapy 

You may have a few systemic therapies together. You also may have systemic treatments along with other treatments, such as radiation therapy. For example, hormone therapy is often used before, during, or after radiation therapy for higher-risk prostate cancer. 

We’ll make a treatment plan just for you. It’s based on your health, what matters to you, and the type of cancer you have. 

These systemic therapies treat prostate cancer:
Hormonal therapy

Hormone therapy works by slowing or blocking prostate cancer cells from growing. Androgens (an-DRUH-jenz) are a group of sex hormones. Testosterone is a type of androgen. If you have prostate cancer, testosterone can make the cancer cells grow. 

Hormone therapy can block testosterone from making cancer cells grow.

Learn more about hormone therapy 

Theranostics

Theranostic treatments use therapy and diagnostic tools together. Theranostics uses targeted imaging molecules to locate cancer cells. Then those same molecules deliver radiation right to cancer cells. Theranostics both finds and treats the cancer cells anywhere in your body. 

MSK experts were leaders in developing theranostics for prostate cancer, including an imaging method called PSMA PET. We co-led clinical trials that led to a treatment called  177Lu-PSMA-617 (Pluvicto®). This molecule attaches to PSMA with radiation that kills the cancer cell. 

You may only have a PSMA PET scan to help us see where the cancer is. 

Learn more about theranostics 

Gene-targeted therapies

Targeted therapies are cancer treatments that target a tumor’s gene changes (mutations or variants). It’s a personal treatment plan just for the type of cancer you have. These medicines often are given by mouth in pill form, or through an IV into your vein.  

Learn more about targeted therapy 

Chemotherapy

Chemotherapy (chemo) is a treatment that uses medicine to stop or slow cancer cells from growing. Chemo puts medicines that target cancer cells into your vein. Most chemo medicines for prostate cancer can go through a standard intravenous (IV) drip. The medicines travel in your bloodstream to kill cancer cells in the body. 

There are a few kinds of chemo medicines for prostate cancer. Your care team will talk with you about the best options. 

Learn more about chemotherapy 

Immunotherapy

Immunotherapy is a form of cancer treatment. It boosts your immune system’s natural ability to fight cancer. Your immune system attacks cancer cells, much the same way it attacks bacteria or viruses.   

Immunotherapy drugs release a brake on the immune system so it can start a stronger attack against cancer. 

Prostate cancer rarely is treated with immunotherapy. It may help some people with a certain genetic mutation (change). A type of immunotherapy drug called  immune checkpoint inhibitors  help the body’s immune cells kill cancer cells. 

Learn more about immunotherapy 

MSK Recommends Bring these questions to your next appointment

When you learn you have prostate cancer, you’ll probably have many questions for your cancer doctor at your first visit. Talking about treatment options with your doctors can help you feel confident when making decisions about your care. 

  • What type of prostate cancer do I have, and what stage is it?
  • What health problems can prostate cancer cause?
  • Did I have all the scans I need to learn the stage?
  • What genetic testing do I need for prostate cancer?
  • What are the best treatment options for the type and stage of prostate cancer I have?
  • When can I start treatment?
  • Can I get prostate cancer treatment at MSK close to my home?
  • What are the risks and side effects of prostate cancer treatment?
  • Do I need surgery?
  • Are there new prostate cancer drugs I can try?
  • Do you have a clinical trial that’s right for me?

Prostate cancer clinical trials

Your care team may talk with you about joining a prostate cancer clinical trial.   

Anyone can join a clinical trial from the very start of treatment, if there’s one that’s right for you. 

Researchers follow strict rules to make sure all clinical trials are safe. The MSK research team will answer your questions and help you get ready for the trial. We follow your progress and keep you safe every step of the way.   

MSK strongly encourages people from all races, genders, ages, and backgrounds to join clinical trials. It’s very important for research studies to include  people from many backgrounds. It’s how our researchers can learn if a new treatment works for everyone, not just one group of people.  

What is a clinical trial?

Clinical trials  are research studies to test new treatments, procedures, or devices to see how well they work. Every cancer treatment given to a person was first tested in a clinical trial.  

Clinical trials can help us learn about new prostate cancer drugs, such as: 

  • What are the ways the drug helps people? 
  • What side effects does the drug cause? 
  • What dose of the drug is safe to give? 
  • How well does the drug treat different types of prostate cancer?  
THE MSK DIFFERENCE

MSK runs one of the country’s largest cancer clinical trials programs. We have around 30 open clinical trials for prostate cancer. At each MSK site, our researchers may screen and match you to a clinical trial. You may have access to new treatments not yet available at most hospitals. 

What are the benefits of joining a clinical trial?

If you join a clinical trial, you may be able to try new drugs to treat your type of prostate cancer. Our patients may get a new treatment at MSK years before it’s offered at most other places.  

Here are some ways enrolling in a clinical trial can help you get the best treatment:

Chance to try new treatments

sometimes years before they’re available to everyone. 

Personal care and support

from your expert care team. 

No extra cost to you

for treatments you get during a clinical trial. 

Innovations at MSK

Our experts are always finding new ways to treat prostate cancer and manage side effects. Explore prostate cancer news from MSK. 

Featured Article Researching New Treatments for Neuroendocrine Prostate Cancer (NEPC)
Genitourinary medical oncologist Dr. Michael Morris, standing in an MSK hallway, is part of a new MSK program for improving treatment for neuroendocrine cancers.
Article Can Exercise Impact Prostate Cancer? A First of its Kind Clinical Trial
Article New Imaging Technique Could Reduce Side Effects of Prostate Cancer Surgery

The MSK prostate cancer team

At MSK, your care is always a team effort. Our care teams combine the skills and experience of many kinds of prostate cancer experts. They work together to give you the best cancer treatment. 

Six members of MSK’s prostate cancer care team, standing in an MSK hallway.

Urologic surgeon Dr. Jonathan S. Fainberg (third from left) with a team of MSK prostate cancer care experts. 

THE MSK DIFFERENCE

MSK has Magnet® designation for our nurses’ excellent patient care, strong leadership, and a culture that values constant improvement. Only about 1 out of every 10 hospitals in the country have Magnet status. It’s one of the highest honors a hospital can earn for nursing excellence.  

What types of MSK experts care for and treat people with prostate cancer?

Your care team has special training in how to diagnose and treat prostate cancer. Their goal is to support you during and after treatment for prostate cancer.  

We take care of the person, not just the cancer. Our experts are here to help you and your family with the emotional, social, and physical effects of cancer. 

Your care team has doctors, nurses, and other healthcare providers who are experts in prostate cancer. They include: 

  • Surgeons 
  • Medical oncologists (cancer doctors) 
  • Radiation oncologists (doctors who uses radiation to treat cancer)   
  • Radiologists (doctors who are experts in imaging) 

Your team meets with a panel of experts who review and talk about your diagnosis. They discuss new ideas and the latest research. This expert panel then works together to choose your treatment plan. 

Meet MSK’s prostate cancer experts 

Your MSK prostate cancer care team may include these experts:
Urologic surgeon

A urologic (yoo-ruh-LAH-jik) surgeon is a doctor with special training in surgery on the genitourinary (jeh-nih-toh-YOOR-ih-nayr-ee) (GU) system. This includes the bladder, kidney, penis, prostate, and testicles. 

Meet the team 

Genitourinary medical oncologist

A genitourinary (GU) medical oncologist is a cancer doctor who specializes in genitourinary (jeh-nih-toh-YOOR-ih-nayr-ee) cancers. This includes bladder, kidney, penis, prostate, and testicular cancers. 

Meet the team 

Radiation oncologist

A radiation oncologist is a cancer doctor with special training in using radiation therapy (RT) to treat cancer with radiation.  

Meet the team 

Radiologist

A radiologist is a doctor with special training in using imaging to diagnose and treat disease. Imaging includes X-rays, sonography, ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). 

Meet the team 

Pathologist

A pathologist is a doctor who uses a microscope to make a diagnosis from cell and tissue samples. They analyze the samples to learn more about a health issue, such as cancer. 

Meet the team 

Social worker

A social worker is a healthcare provider with special training in helping people cope with the problems in their lives. They support you emotionally by providing counseling and practical help.  

Meet the team

Advanced practice provider

An advanced practice provider is a healthcare provider with special training who works alone or with your doctor to care for you. Examples are nurse practitioners (NPs) and physician assistants (PAs). 

Meet the team 

MSK Difference Our approach to care

If you have cancer, you need a team of experts who cares for you with kindness and respect.   

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We want to get to know what’s important to you

You have cancer, but that does not define who you are as a person. We know you want to get back to the life you had before cancer treatment. At MSK, we listen. We’re here to support what matters most to you. 

We’ll make a personal plan, just for you

Your care team builds a treatment plan just for you. It’s based on your age, risk factors, genetics, health, and preferences. 

Your treatment plan will describe therapies and services during and after treatment. We’ll make sure your plan provides excellent cancer care that fits your personal needs. 

We’re a team that works together on your care

Our Care Advisors match you with a team of doctors and other healthcare providers. Your team can include experts in rehabilitation, integrative medicine and wellness, or social work. Everyone works together to give you the support you need. 

We offer support to you and your loved ones

Our care goes far beyond cancer care. At MSK, we have experts who help improve your total health. For example, we have programs for pain management, and help to quit smoking. Our Caregivers Clinic offers counseling to support your whole family. 

Request an appointment

Talk with an MSK Care Advisor. We're here 24 hours a day, 7 days a week. 

Prostate cancer support services and programs

Linda Mathew is at MSK in New York City.

Clinical social worker Linda Mathew is on a team that supports you and your caregivers during and after treatment for prostate cancer.

How does MSK support people with prostate cancer?

Cancer treatment affects your body and emotions. The experience is not the same for everyone. We’ll support you during your treatment. 

But you’re also a person with a life beyond cancer. We want to help you get back to it. That’s why we have many programs and services to support you and your loved ones. 

You can connect with other people going through cancer treatment in our virtual support groups, led by a social worker

Or, you may need help with side effects of treatment. We have experts with special training in treating pain.   

Your caregivers are a very important part of your care team. They need support, too. We have a Caregivers Clinic to help your loved ones cope with cancer.   

Ways we support you

Our  Integrative Medicine and Wellness Service  offers complementary, natural, and holistic treatments. They include  acupuncture, meditation, massage therapy, yoga, and exercise. 

You may want support to cope with side effects of prostate cancer treatment. These may include pain, fatigue (feeling very tired), nerve problems, nausea, insomnia, and stress. 

Without using prescription drugs,  integrative therapies  can help improve and control side effects of cancer treatment. 

 Integrative medicine services are available in New York City, New Jersey, Westchester, and on Long Island.  

Pain management is an important part of cancer care. MSK was the first cancer center in the country to have a service just for  treating pain  in people with cancer. 

Our pain experts will help relieve or manage pain after surgery. They can help while you’re still in the hospital, and after you’re home. 

We have experts who manage the symptoms and side effects of cancer treatment, such as  nausea during chemotherapy

We offer  counseling and support  to help you  manage anxiety,  depression, anger, or loneliness. There are individual and group counseling sessions, both in person and through  telemedicine visits. Counseling is open to you and your family, separately or together. 

We also run  support groups and programs  if you want to talk with other people going through a similar experience. Our  social workers  can offer information about how to talk about your diagnosis with family members, work colleagues, and friends.  

Cancer treatment can affect your digestion (how your body breaks down the food you eat). It can change your taste, how you eat, and how hungry you are.   

Our clinical dietitian nutritionists can help with:  

  • Planning healthy meals at home.  
  • Advice about special diets.  
  • Dealing with food allergies.  
  • Managing symptoms such as weight loss or gain, and loss of appetite (not feeling hungry).  
  • Eating healthy to help recovery. 

Cancer affects your sex life in both physical and emotional ways. It’s normal to think about how cancer treatment may affect your sex life.  

Our  Male Sexual & Reproductive Medicine Program  can help. They have experts in the physical symptoms and emotional challenges that may affect your sex life.  

We can talk with you about physical changes, including erectile dysfunction (ED), and low testosterone levels, that affect intimacy.   

THE MSK DIFFERENCE

MSK is a place where people of all genders and sexual orientations feel welcome and treated with respect. Our LGBTQI+ Cancer Care Program gives you the support you need during cancer care. It’s for LGBTQI+ people getting screened or treated at MSK, or in our survivorship program.  

MSK’s prostate cancer treatment locations

We believe cancer care should be as convenient as possible. We have prostate cancer treatment locations in New York City, Westchester, on Long Island, and in New Jersey. 

At our locations, you can meet with your care team and get your prostate cancer treatment. You may be able to have chemotherapy or radiation therapy, or join a clinical trial. 

MSK brings its expert care closer to you so you can get back home to what matters most. 

A map of MSK’s treatment locations in the New York City area

Expert cancer care where you need it

Many of MSK’s prostate cancer treatments and services are available at locations across New York and New Jersey.

We’ll guide you about where you can go for check-ups, procedures, or treatments, based on your diagnosis and treatments. 

Last updated July 6, 2026
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