National Colonoscopy Study (NCS)

National Colonoscopy Study (NCS)



Ann Zauber at 646-735-8160

Study Map

The National Colonoscopy Study is a multi-center, randomized controlled trial funded by NCI. (R01-CA079572) The completed, three-year Phase I feasibility trial investigated Colonoscopy screening versus Usual Care for colorectal cancer in 1402 participants. Currently, 3526 participants are enrolled in Phase II, evaluating colorectal cancer screening with Colonoscopy versus an annual Fecal Occult Blood Test (FOBT).
The study is closed to accrual.

MSK Principal Investigator
Ann G. Zauber, PhD

MSK Co-Principal Investigator
Sidney Winawer, MD

Study Objective

  • Compare the neoplastic outcome of participants at average risk for colorectal cancer who undergo Colonoscopy vs annual Fecal Occult Blood Tests.
  • Evaluate the endoscopic and clinical resources required for these screening methods in these participants.
  • Relate the benefit-to-harm ratio in participants undergoing these screening methods and determine the level of adherence of participants undergoing these screening methods.

Why is this important?

The National Colonoscopy Study will determine if a screening colonoscopy is as good as an annual Fecal Occult Blood Test (FOBT) for early detection of polyps in the colon.

Project Members