Ann Zauber, PhD

Member, Attending Biostatistician

Pictured: Ann Zauber

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Johns Hopkins University

Current Research Interests

Dr. Zauber’s primary research focus is identifying and assessing ways to prevent and reduce the burden of colorectal cancer incidence and mortality, specifically through screening and surveillance. Her work involves population-based statistical modeling and precision medicine to identify effective and cost-effective screening strategies in order to better inform health policy and randomized clinical trials. Dr. Zauber leads the Cancer Intervention and Surveillance Modeling Network (CISNET) colorectal group, a multi-center group of microsimulation modelers sponsored by the National Cancer Institute. Her team conducted decision analyses for the 2008 and 2016 United States Preventive Services Task Force’s colorectal cancer screening recommendations on optimal age to begin and end screening, screening intervals, and screening modalities. Recently her modeling group conducted a decision analysis for the American Cancer Society for age to begin screening given the rising incidence rates for colorectal cancer in younger cohorts. The American Cancer Society recommended lowering the age to begin CRC screening from age 50 to age 45. The CISNET decision analyses have also informed colorectal cancer screening strategies for higher risk populations such as those with Cystic Fibrosis or Lynch Syndrome. Dr. Zauber and her CISNET team have worked closely with Centers for Medicare and Medicaid Services Centers for Disease Control and Prevention on colorectal cancer screening and prevention, and the cost-effectiveness of available and novel screening tests in average and genetically predisposed (high risk) populations. Other publications include assessment of the impact of a co-pay loophole on colonoscopy screening for Medicare beneficiaries, and projection of colorectal cancer incidence and mortality reductions if 80% of US population were screened by 2018. Dr. Zauber is also a leader in screening studies. She was the Principal Investigator for the National Colonoscopy Study, a multi-center randomized controlled trial for screening colonoscopy and fecal occult blood test, and a co-Principal Investigator on the NCI PROSPR I consortium. She demonstrated in the National Polyp Study that removal of adenomas, the precursor lesion of colorectal cancer, reduces both incidence and mortality of colorectal cancer. She served on the advisory panel for the colorectal cancer screening recommendations for the International Agency for Cancer Research.  Additionally, Dr. Zauber continues to serve as lead biostatistician on many national and international studies including, the Nordic-European Initiative on Colorectal Cancer, and a pilot study on screening in Nigeria. She is a Fellow of the American Statistical Association and of the American Gastroenterology Association.


Selected peer-reviewed publications:

  1. Knudsen AB, Zauber AG, Rutter CM, et al. Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the US Preventive Services Task Force. JAMA. 2016;315(23):2595-609.
  2. Zauber AG, Winawer SJ, O’brien MJ, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med. 2012;366(8):687-96.
  3. Zauber AG, Lansdorp-vogelaar I, Knudsen AB, Wilschut J, Van ballegooijen M, Kuntz KM. Evaluating test strategies for colorectal cancer screening: a decision analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;149(9):659-69.
  4. Lansdorp-Vogelaar I, Gulati R, Mariotto AB, Schechter CB, de Carvalho TM, Knudsen AB, van Ravesteyn NT, Heijnsdijk EA, Pabiniak C, van Ballegooijen M, Rutter CM, Kuntz KM, Feuer EJ, Etzioni R, de Koning HJ, Zauber AG, Mandelblatt JS. Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms and benefits. Ann Intern Med. 2014;161(2):104-12.
  5. Corley DA, Jensen CD, Marks AR, Zhao WK, Lee JK, Doubeni CA, Zauber AG, de Boer J, Fireman BH, Schottinger JE, Quinn VP, Ghai NR, Levin TR, Quesenberry CP. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014;370(14):1298-306.

View a full listing of Ann Zauber’s journal articles.

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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Ann Zauber discloses the following relationships and financial interests:

  • American Cancer Society
    Provision of Services (uncompensated)
  • American Gastroenterological Association (AGA)
    Provision of Services (uncompensated)
  • Fight Colorectal Cancer
    Provision of Services (uncompensated)

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