Research Labs

Chemical Biologist Minkui Luo develops cutting-edge tools, technologies and concepts to annotate functions of protein-posttranslational modifications and designs inhibitors for cancer therapies.

John Maciejowski studies how genomic instability shapes cancer. His lab works on how tumors keep the immune system from detecting their own displaced DNA, and on the patterns of mutation and oncogene amplification that instability writes into the cancer genome.

Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.

The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.

Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

Molecular biologist Simon Powell investigates DNA replication and recombination, chromosome dynamics, and human genetics.

Molecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.

The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.

The Sheu-Gruttadauria Lab investigates how biomolecular condensates and biological phase transitions shape gene expression in physiology and disease.

Cell biologist Meng-Fu Bryan Tsou studies cell cycle control of centrosome duplication and degeneration, as well as cilia assembly and disassembly.