- ju hua
- chu hua
For Patients & Caregivers
Chrysanthemum has not been shown to treat or prevent cancer.
Chrysanthemum has been used in traditional Chinese medicine for centuries, but very little laboratory research has been conducted. It is thought that the flower causes dilation of the coronary arteries and therefore increases blood flow to the heart, but this effect has not been clearly documented in humans. The mechanism underlying its anti-inflammatory, antibacterial, and fever-reducing activities is not known. Some studies indicate that chrysanthemum extracts can kill cancer cells in the laboratory setting, but it is not known whether this effect occurs in the human body.
Chrysanthemum is one of the components in PC-SPES, which has been used against prostate cancer in clinical trials.
- To treat angina
Chrysanthemum is used to treat angina in traditional Chinese medicine, but research has not been conducted.
- To prevent and treat common cold
Although chrysanthemum is used to treat the common cold in traditional Chinese medicine, it has not been studied in humans.
- To reduce fever
Chrysanthemum is used as a fever reducer in traditional Chinese medicine but human data are lacking.
- To reduce high blood pressure
Although chrysanthemum is used to treat high blood pressure in traditional Chinese medicine, clinical studies have not been conducted.
For Healthcare Professionals
Derived from the flower and aerial parts of the plant, Chrysanthemum is used commonly in traditional Chinese medicine to treat hypertension, angina, and fever. In vitro and animal studies indicate cytotoxic (10)(12), anti-inflammatory (13), immunomodulatory (14), and neuroprotective (9)(11) properties. Chrysanthemum was also shown to reverse multidrug resistance in human breast cancer cells (15); and topical application was found effective against atopic dermatitis in mice (16).
Clinical trials have yet to be conducted to determine these effects in humans.
Chrysanthemum is one of the eight components of PC-SPES, an herbal formulation used in trials of prostate cancer.
In vitro studies indicate that chrysanthemum has cytotoxic (4) and antibacterial (6) properties. Extracts of chrysanthemum showed no effect on insulin levels (7). In a study of mice, chrysanthemum significantly decreased serum IgE, IgG1, IL-4, and IFN-γ levels and reduced mRNA levels of IFN-γ, IL-4, and IL-13 in dorsal skin lesion (16).
Chrysanthemum was shown to reverse multidrug resistance in human breast cancer (MCF-7/ADR) cells via an increase in Rh123 accumulation and a decrease of Rh123 efflux indicating a blockage of the activity of P-gp (15). In another study, chrysanthemum induced apoptosis in various tumor cells via inhibition of the JAK1/2 and signal transducer and activator of transcription 3 (STAT3) signaling pathways (12).
Antihypertensive drugs: Theoretically, chrysanthemum may have an additive hypotensive effect.
Cytochrome P450 (CYP) 3A4 substrates: Chrysanthemum extract induces CYP3A4 by activating pregnane X receptor (PXR). This may increase the clearance of substrate drugs when used concomitantly (17).