MATCHES: Making Telehealth Delivery of Cancer Care at Home Effective and Safe

The MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Telehealth Research Center aims to build the evidence base necessary to establish best practices for telehealth-enabled cancer care. The overarching goal of the Center is to create a research hub that generates evidence, trains investigators, and develops the research methods required to ignite the field of precision cancer care delivery. We aim to develop a new paradigm in oncology—precision delivery—with the ultimate goal of matching individual patients with the most beneficial combination of clinic-based or telehealth-supported home-setting care.

Our specific aims are:

  • to conduct impactful pragmatic trials of telehealth in oncology
  • to analyze a large existing cache of multidimensional observational data characterizing telehealth utilization and outcomes
  • to train investigators and equip them with the skills necessary to innovate within an evidence-based framework
  • to integrate telehealth with other data streams and create and apply analytic methods to transform the field of precision care delivery.

An Administrative Core will coordinate activities and engage feedback from internal and external stakeholders—including patients and the oncology workforce. Our Clinical Practice Network serves as an innovation laboratory and comprises 7 outpatient clinics in NY and NJ with a shared informatics ecosystem including telehealth capacity, digital monitoring, and a highly trafficked patient portal. This will enable us to launch and execute a large pragmatic trial comparing in-person care to telehealth, with resources designed to support home-based care using a cluster-randomized design.

The Research & Methods Core will support the Center by applying data science methods to extract and synthesize insights from telehealth and other data streams to develop methods relevant to advancing precision cancer care delivery and the goals of equity, efficacy, and efficiency to create an optimal experience for people being treated for cancer.







Amy I. Laughlin, MD, MSHP
Orlando Health Cancer Institute

Building and rapidly scaling oncology treatment at home during the COVID pandemic

Amy Iarrobino Laughlin, MD, is a Medical Oncologist and Assistant Quality Officer at Orlando Health Cancer Institute in Orlando, Florida. She was previously a fellow in Hematology and Oncology at Penn Medicine and a PC3I Innovation Fellow. She completed her residency at the Hospital of the University of Pennsylvania during which time she was a member of the Healthcare Leadership and Quality Track with projects focused on inpatient oncology team communication and advance care planning. Her research interest is in optimizing and transforming cancer care, with particular focus on breast cancer and use of patient centered technology.

May 23, 2023

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Kathi Mooney, PhD, RN

University of Utah

Use to tele-oncology in hospital at home models

Dr. Mooney is a distinguished professor at the University of Utah College of Nursing and co-leader of the Cancer Control and Population Sciences Program at the Huntsman Cancer Institute. Her research is focused on understanding and reducing morbidity from cancer and treatment-related physical and psychosocial symptoms. She designs and tests technology-enabled interventions to improve quality of life for cancer patients and their families. She evaluates new cancer care delivery models that add value. The aim is to improve cancer patients’ and their families’ outcomes through care delivered in their homes and communities including families living in rural and frontier settings.,_RN,_FAAN/hm/index.hml

July 11, 2023

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Shaalan Beg, MD, MS
UT Southwestern Medical Center


Employing tele-oncology to improve access to clinical trials

Dr. Beg is vice president oncology, Science 37 and adjunct association professor, Hematology and Oncology, University of Texas Southwestern Medical Center.

A storied researcher and oncologist, Dr. Beg came to Science 37 from the University of Texas, Southwestern Medical Center in Dallas, TX where he served as Medical Director for the Clinical Research Office at the Simmons Comprehensive Cancer Center and held the position of Director Gastrointestinal Medical Oncology and Associate Professor of Hematology and Medical Oncology.

Nationally, Dr. Beg is a member of the American Society of Clinical Oncology (ASCO) and the ECOG-ACRIN Clinical Research Group, having held a number of committee positions in those organizations. He is a graduate of ASCO’s Leadership Development Program and has been a member of the Pancreatic Cancer Task Force of the National Cancer Institute (NCI) GI Cancer Steering Committee.

September 12, 2023

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Adrian Aguilera, PhD
Associate Professor

UC Berkeley – Social Welfare

UC San Francisco – Psychiatry & Behavior Sciences

Digital Health Equity and Access

Dr. Adrian Aguilera is an Associate Professor in the School of Social Welfare at UC Berkeley and the Department of Psychiatry and Behavioral Sciences at UC San Francisco (UCSF). Dr. Aguilera directs the Digital Health Equity and Access Lab(link is external) (dHEAL) and previously directed the Latinx Center of Excellence in Behavioral Health. Dr. Aguilera’s research is focused on developing and testing technology-based interventions to address health disparities in low-income and vulnerable populations, with an emphasis on Latinx populations. Dr. Aguilera’s current work has focused on utilizing mobile phone technology to improve mental health interventions in primary care settings.

Dr. Aguilera’s work has been funded by the National Institutes of Health, the Robert Wood Johnson Foundation, the Agency for Healthcare Research and Quality, and the Health Resources and Services Administration among others.

October 17, 2023


MATCHES Telehealth Research Center Investigative Team
Erin Bange, Memorial Sloan Kettering medical oncologist
Erin Bange

Assistant Attending Physician

Carol L. Brown, MD, FACOG, FACS
Carol L. Brown

Senior Vice President and Chief Health Equity Officer; Nicholls-Biondi Chair for Health Equity at Memorial Sloan Kettering; Vice Chair Health Equity, Department of Surgery

Memorial Sloan Kettering medical oncologist Robert Daly
Robert Daly

Assistant Attending Physician

Paul A. Hamlin, MD
Paul A. Hamlin

Attending Physician

Psychologist Jennifer Hay
Jennifer L. Hay

Member and Attending Psychologist

Memorial Sloan Kettering Medical Oncologist Michael Morris
Michael J. Morris

Prostate Cancer Section Head, Genitourinary Oncology; Steven A. Greenberg Chair in Prostate Cancer Research

Memorial Sloan Kettering medical oncologist Diane Reidy Lagunes
Diane Reidy-Lagunes

Vice Chair of Oncology Operations, Regional Care Network; Past President, MSK Medical Staff; Creator and Host, Cancer Straight Talk Podcast

Memorial Sloan Kettering Medical Oncologist Deb Schrag
Deb Schrag

Chair, Department of Medicine, George J. Bosl Chair at Memorial Sloan Kettering Cancer Center

Memorial Sloan Kettering internist & Chief Health Informatics Officer Peter Stetson
Peter D. Stetson

Chief Health Informatics Officer


Protocol 23-057 MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Observational Research Protocol

The MATCHES (Making Telehealth Delivery of Cancer Care at Home Effective and Safe) Telehealth Research Center will perform integration and pre-processing of complex synchronous and asynchronous data, data harmonization for telehealth evaluation and development of novel research methods. The overall goal of the Center is to optimize and personalize telehealth care delivery for cancer patients and survivors by deploying a novel intervention for cancer care delivery at home. The major tasks of this retrospective protocol are to 1) synthesize complex multimodal, multilayer asynchronous and synchronous data from trial data and MSK-wide data; 2) develop common data elements and facilitate data sharing across the Center; 3) track, manage, and analyze data on processes and outcomes of telehealth implementation, as well as clinical-effectiveness outcomes; 4) perform quality-control and coordination of all data use; 5) develop an analytic pipeline for digital biomarker discovery.

  • Aim 1: To assemble an observational database by integrating synchronous and asynchronous data for the development of research methods in telehealth.
  • Aim 2: To develop an analytic pipeline for digital biomarker discovery.
  • Aim 3: To explore patterns of telehealth use by patient, clinician, and clinic site factors.
  • Aim 4: To explore the effect of telehealth on key clinical outcomes such as overall survival, health care utilization, quality of life, and safety.
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