Research Labs

Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.

Physician-scientist Andrew Intlekofer investigates why cancer cells depend on specific pathways of nutrient metabolism.

Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.

The Lee laboratory studies the mechanisms governing homeostatic turnover and reparative programs in stem cells, with a focus on elucidating how tissue perturbations lead to lung disease.

Immunologist Ming Li studies mechanisms of immune regulation, and their relevance to diseases including cancer.

We develop and clinically deploy novel computational algorithms for analyzing multiscale, multimodal biomedical imaging data.

The Osorio Lab studies the mechanisms of antibody-mediated immunity, with a focus on myeloid cell reprograming to advance cancer immunotherapies.

Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.

Computational biologist Dana Pe’er combines single-cell and spatial profiling technologies with machine learning approaches to address fundamental questions in gene regulation, cellular plasticity and cell-cell communication in the contexts of cancer, immunity and development.

Immunologist Justin Perry investigates homeostatic apoptotic cell clearance and how this process is exploited during cancer development and progression.