Research Labs

The Huangfu laboratory uses human pluripotent stem cells (hPSCs) as a powerful genetic model to interrogate the transcriptional and epigenetic mechanisms underlying cell fate decisions in development and disease.

Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.

Molecular biologist Prasad Jallepalli studies the mechanisms that ensure accurate chromosome transmission in human cells.

The Jasin laboratory focuses on double-strand break repair and genomic integrity in mammalian cells and the relationship to tumor suppression.

Cell biologist Xuejun Jiang studies programmed cell death, molecular mechanisms, and their roles in tumorigenesis.

Cancer biologist and pediatric oncologist Alex Kentsis leads research in the functional proteomics and molecular pharmacology of refractory childhood cancers.

Molecular pathologist Marc Ladanyi studies the molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.

The Lai laboratory integrates genetics, biochemistry, and genomewide approaches to study diverse regulatory networks during patterning and behavior.

The Lareau Lab synthesizes computational and experimental genomics methods to study how immune cells in our bodies adapt, expand, differentiate, and evolve over an individual’s lifetime.