Research Labs

Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.

Molecular and cell biologist Christine Mayr studies how 3′UTRs regulate protein functions and how mRNAs contribute to cytoplasmic organization.

Physician-scientist Ingo Mellinghoff studies signal transduction alterations in primary brain tumors.

Our group, the Laboratory of Experimental Cancer Immunogenomics, is a multi-disciplinary team of cancer scientists working at the intersection of genomics, molecular genetics, animal modeling, and biostatistical data sciences.

Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.

Developmental biologist Luis F. Parada uses genetically engineered mouse models to study neurofibromatosis, brain tumors, cancer stem cells, and tumor progression.

Computational biologist Dana Pe’er combines single-cell and spatial profiling technologies with machine learning approaches to address fundamental questions in gene regulation, cellular plasticity and cell-cell communication in the contexts of cancer, immunity and development.

Immunologist Justin Perry investigates homeostatic apoptotic cell clearance and how this process is exploited during cancer development and progression.

Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

Molecular Pharmacology Program Member David Scheinberg focuses on the discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.