Sarcoma Center Funded Research Projects

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A core focus of the Sarcoma Center at Memorial Sloan Kettering is to provide funding for innovative sarcoma-related research through the Sarcoma Fund grant that was established in 2019.

2020 Awards

Luis Parada
Cancer Biology and Genetics Program
Project: Cancer Stem Cells in NF1-Associated MPNST

Nai-Kong Cheung
Department of Pediatrics
Memorial Hospital Research Laboratories

Project: CD24xCD3 Bispecific Antibody (BsAb) for Compartmental Immunotherapy and Radioimmunotherapy in Desmoplastic Small Round Cell Tumors

Alex Kentsis
Department of Pediatrics
Molecular Pharmacology Program

Project: Combination Epigenetic Therapies for BAF-Deficient Sarcomas

Sandra D’Angelo
Department of Medicine
Project: The Efficacy of CDK4 Inhibition and Immune Checkpoint Blockade in Locally Advanced, Resectable, and Metastatic Dedifferentiated Liposarcoma — Identifying Senescence and Immune Biomarkers Predictive of Clinical Benefit

2019 Awards

Ping Chi
Department of Medicine
Human Oncology and Pathogenesis Program

Project: Immune Evasion and Immunotherapeutic Intervention of PRC2-Deficient Tumors

Aimee Crago
Department of Surgery
Memorial Hospital Research Laboratories

Project: Investigating HIF1A Signaling to Identify Predictive Markers and Therapeutic Targets in Desmoid Tumors

Frederic Geissmann
Immunology Program
Project: Targeting Lung Macrophages in Metastatic Osteosarcoma

Hans-Guido Wendel
Cancer Biology and Genetics Program
Project: Determinants of Escape from Natural Killer Cells in Sarcoma

Multipart Sarcoma-Related Projects

Andrew Kung
Department of Pediatrics
Project: Optimizing T Cell-Based Immunotherapies for Pediatric Sarcomas and AML

Two sarcoma research projects are being funded as part of this larger project:

Christopher Klebanoff
Department of Medicine
Human Oncology and Pathogenesis Program

Project: TCR Immunotherapy Targeting Shared Neoantigens Derived from Sarcoma-Associated EWSR1-WT1 Oncogenic Gene Fusions

Renier Brentjens
Department of Medicine
Human Oncology and Pathogenesis Program

Project: Axl/EphA2 Dual Targeted CAR T Cells Modified to Secrete the IL-18 Cytokine for the Treatment of Osteosarcoma

Career Development Awards

These awards are given to early-career researchers.

2021 Awards

Evan Rosenbaum
Department of Medicine
Project: A Phase II Study of the Dual Adenosine Receptor Antagonist AB928 with the Anti-PD-1 Antibody Zimberelimab in Patients with Advanced Dedifferentiated Liposarcoma and Undifferentiated Pleomorphic Sarcoma

Jason Chan
Department of Medicine
Cancer Biology and Genetics Program

Project: Dissecting Tumor Heterogeneity in Undifferentiated Pleomorphic Sarcomas

2020 Awards

Benjamin Nacev
Department of Medicine
Project: Identifying Chromatin-Pathway Dependencies in FUS-DDIT3 Expressing Myxoid Liposarcoma Using Chemical and Genetic Strategies

Ciara Kelly
Department of Medicine
Project: Development of a Customized, Multi-Modal Treatment Response Assessment Measurement in Gastrointestinal Stromal Tumors 

2019 Awards

Sandra D’Angelo
Department of Medicine
Project: CDK4 Inhibition to Trigger Anti-Tumor Immunity and Augment Efficacy of Combined Checkpoint Blockade in Patients with Metastatic Liposarcomas