The following scientists and clinicians are winners of the Chanel Endowment to Fund Survivorship Research and Society of Memorial Sloan Kettering Cancer Center grants.
Chanel Endowment to Fund Survivorship Research
An endowment from Chanel provides funding for well-designed, novel clinical and basic studies focused on medical aspects of cancer survivors. All applications are peer-reviewed for outstanding scientific merit by key leadership.
Helena Furberg-Barnes, MSPH, PhD, Epidemiology-Biostatistics
Project Title: Body composition and the obesity paradox in renal cell carcinoma
Obesity is a risk factor for getting kidney cancer but patients with high BMI survive longer than those who have normal BMI. Reasons for this “obesity paradox” are unknown. In this study we are refining BMI into specific body composition variables (like muscle and amount of fat) and examining how patient body composition is associated with tumor features, survival and tumor genomics.
Andrea Barrio, MD, FACS, Department of Surgery
Project Title: A Prospective Surveillance Program for Assessment and Treatment of Breast Cancer-Related Lymphedema after Axillary Lymph Node Dissection
This study will prospectively determine the incidence of upper extremity lymphedema after axillary lymph node dissection using rigorous measurement protocols. We will also evaluate the role of inflammatory biomarkers, as well as traditional patient and treatment factors, in the pathogenesis of lymphedema. Finally we will investigate the association between patient-reported symptoms of lymphedema and measured lymphedema to define an optimal threshold for intervention.
Elizabeth Comen, MD, Department of Medicine
Project Title: CYP2D6 phenotype, tamoxifen treatment and risk of contralateral breast cancer in the WECARE study population
The objective of this study is to fully characterize the CYP2D6 phenotype and determine its impact on the association between tamoxifen and risk of CBC in the WECARE study population. This will provide crucial clinical information and a significant step toward developing personalized breast cancer treatment and surveillance strategies geared toward reducing the incidence of CBC.
Anthony F. Yu, MD, Cardiology Service, Department of Medicine
Project Title: A Phase 2 Trial of Carvedilol for the Prevention of Trastuzumab Induced Cardiac Dysfunction among Women with HER2-Positive Breast Cancer Using Myocardial Strain Imaging for Early Risk Stratification
This intervention trial is designed to investigate the effectiveness of carvedilol therapy at preventing the development of cardiotoxicity in breast cancer patients treated with trastuzumab who are identified as being at risk because of subclinical LV dysfunction by 2D speckle tracking, a novel echocardiographic modality.
Danielle Novetsky Friedman, MD, Department of Pediatrics
Project Title: Assessing Insulin Sensitivity and Diabetes Mellitus Risk in Neuroblastoma Survivors Treated with Abdominal Irradiation: A Pilot Study
This pilot study uses a single-institutional cohort of neuroblastoma survivors to ascertain mechanisms leading to diabetes mellitus in this high-risk population.
Darren R. Feldman, MD, Genitourinary Oncology Service, Department of Medicine
Project Title: Investigation into the Mechanism of Cisplatin-Induced Cardiovascular Toxicity: A Study of Acute Changes in Endothelial Function Following Cisplatin-Based Chemotherapy in Men with Germ Cell Tumors (GCT)
This is a pilot longitudinal study testing changes in endothelial function among male germ cell tumor patients treated with cisplatin-based chemotherapy or surgery alone.
Shrujal S. Baxi, MD, MPH, Head and Neck Oncology Service, Department of Medicine
Project Title: Competing Causes of Mortality in Survivors of Head and Neck Squamous Cell Carcinoma
This study assesses long-term mortality rates and identifies predisposing risk factors for competing causes of mortality in survivors of head and neck squamous cell carcinoma.
Victoria Blinder, MD, MSc, Breast Cancer Medicine Service, Department of Medicine
Project Title: Ethnic Differences in the Impact of Breast Cancer on Employment Status, Financial Situation, and Quality of Life
This matched cohort study aims to identify and describe ethnic differences in employment status, financial situation, and quality of life after treatment for breast cancer, with the ultimate goal of developing interventions that may significantly improve the lives of breast cancer survivors.
Elizabeth Ryan, PhD, Department of Psychiatry & Behavioral Sciences
Project Title: Rehabilitation of Chemobrain in Breast Cancer Survivors
This study will investigate whether breast cancer survivors with demonstrated cognitive difficulties who have received chemotherapy can improve cognitive side effects through use of a five-week rehabilitation software training program.
Tim Ahles, PhD, Department of Psychiatry & Behavioral Sciences
Project Title: Chemotherapy-Induced Cognitive Change and Deoxyribonucleic Acid (DNA) Damage in Breast Cancer Survivors
The primary objective of this project is to obtain preliminary data regarding the association between DNA damage associated with chemotherapy and cognitive dysfunction in breast cancer survivors.
Kevin Oeffinger, MD, Department of Pediatrics
Project Title: Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Leukemia Following Total Body Irradiation and Stem Cell Transplant
The long-term objective of the study is to reduce risk and prevent the development of insulin resistance, glucose intolerance, diabetes mellitus, dyslipidemia, metabolic syndrome, and premature cardiovascular disease in women who were treated with total body irradiation (TBI) followed by an allogeneic or autologous stem cell transplant. If the amount of visceral adipose tissue is increased in women who were treated with TBI, and if this outcome is associated with insulin resistance and dyslipidemia (as it in the general population), then targeted interventions will be designed to reduce that risk.
David Weinstock, MD, Bone Marrow Transplant Service, Infectious Diseases Service, Department of Medicine
Project Title: Assaying Risk for Secondary Leukemia Among Women Treated for Breast Cancer
This study proposes to evaluate a subset of women who develop acute myelogenous leukemia/myelodysplastic syndrome (t-AML) after treatment for breast cancer to determine if they have identifiable defects in double-strand break repair that confer an increased predisposition to leukemogenesis. t-AML is believed to result from the misrepair of DNA double-strand breaks introduced by clastogenic chemotherapy and radiation.
Society of Memorial Sloan Kettering Cancer Center
When the Survivorship Initiative was launched, the Society of Memorial Sloan Kettering Cancer Center graciously funded a competitive grant process to encourage scientists and physicians across the Center to work collaboratively in order to identify and develop interventions to reduce the long-term effects of treatment on cancer survivors.
Jennifer Ford, PhD, Department of Pediatrics; Department of Psychiatry and Behavioral Sciences
Project Title: Development of a Computer-Assisted Survivor Screening for Adult Survivors of Childhood Cancer
The goal of this study is to determine the feasibility of a computer-assisted survivor screening for adult survivors of childhood cancer. Given the recognized need for routine psychological assessment and care for survivors, these responses will be used to tailor the assessment of heath status, depression, and psychological distress so appropriate interventions can be offered.
David Kissane, MD, Department of Psychiatry and Behavioral Sciences
Project Title: Quality of Life Issues in Head & Neck Cancer Survivors: Shame, Stigma, Demoralization, or Adaptation
The broad objective of this study is to assess quality of life and psychosocial adaptation in head and neck cancer patients undergoing treatment so that empirically informed interventions can be developed to improve the adaptation of these patients. It is known that these patients suffer significant functional, cosmetic, emotional, and guilt-related problems. Identification and measurement of the prevalence of these problems will improve understanding of these complex issues and lead to improved treatments.
Bruce Rapkin, PhD, Department of Psychiatry and Behavioral Sciences
Project Title: Fostering the Development of Community-Based Networks of Cancer for Cancer Survivors: A Study of Service Capacities Among Health Care Agencies in New York
This study will examine the service-delivery system for support and care available for cancer survivors in the New York metropolitan area and identify referral patterns, gaps in service, and barriers to care within the delivery system. Working with the New York State Department of Health, results will be used to develop and enhance services for cancer survivors.
Charles Sklar, MD, Department of Pediatrics
Project Title: Disorders of Glucose Homeostasis in Young Adults Treated with Total Body Irradiation During Childhood: A Pilot Study
Endocrine sequelae are present in up to 40 percent of childhood cancer survivors, and numerous investigators have reported an increased risk of insulin resistance and the metabolic syndrome in patients who have undergone bone marrow/stem cell transplant. The aim of this study is to: 1) assess the prevalence of disorders of glucose homeostasis, including type-1 diabetes, insulin resistance, and type-2 diabetes in young adults treated with total body irradiation during childhood, and 2) determine the risk factors of such disorders, including patient characteristics, treatment variables and treatment complications.
Trudy Small, MD, Bone Marrow Transplant Service, Department of Clinical Laboratories
Project Title: Assessment of Vaccine Efficacy in Adult Survivors of Autologous Hematopoietic Cell Transplantation
In order to assure that cancer survivors who have been treated with high-dose therapy with autologous hematopoietic cell transplantation (autoHCT) are not vulnerable to outbreaks of vaccine-preventable disease such as measles, influenza, hepatitis B, and antibiotic-resistant pneumococcus, this study will assess the ability of autoHCT recipients to respond to specific vaccinations and develop evidence-based recommendations for the timing and scheduling of revaccination post autoHCT.