The following scientists and clinicians are winners of the Chanel Endowment to Fund Survivorship Research and the Population Sciences Research Program grants.
Chanel Endowment to Fund Survivorship Research
An endowment from Chanel provides funding for well-designed, novel clinical and basic studies focused on medical aspects of cancer survivors. All applications are peer-reviewed for outstanding scientific merit by key leadership.
Fumiko Chino, MD, Radiation Oncology
Project Title: “Running on Empty”: Financial Literacy, Financial Capacity and Enduring Financial Toxicity in Young Adult Cancer Survivors
Financial toxicity, the economic hardship that results from cancer treatment, has been reported at higher rates among young adult cancer survivors than older survivors.Financial toxicity can result in negative effects on survivors’ quality of life, including increased risk for bankruptcy, asset depletion, medical debt, and high levels of finance-related anxiety, worry, and stress. This study aims to measure financial toxicity in young adult cancer survivors while also assessing their financial capability, financial health literacy, and the impact of financial toxicity on survivorship health services utilization.
Jessica Scott, PhD, Department of Medicine
Project Title: The MSK Digital Health Cohort (MSK-DHC): A Pan-Cancer Survivorship Study
A comprehensive map of individual physical activity, functional performance, and demographic, and clinical data is not available in any pan-cancer population. The MSK-DHC will integrate previously unavailable, novel raw high dimensional digital health data with demographic and clinical data to establish an unparalleled infrastructure with enormous discovery and translational value related to survivorship research and clinical care.
Talya Salz, PhD, Epidemiology-Biostatistics
Project Title: Chronic opioid therapy and opioid-related harms among older cancer survivors
Cancer survivors may have greater pain management needs, experience greater health risks, and have less coordinated care than those who have never had cancer. This study uses linked SEER-Medicare data to characterize opioid use and opioid-related harms among older cancer survivors.
Shari Goldfarb, MD, Department of Medicine
Project Title: Understanding Fertility Decisions and Outcomes of Young Breast Cancer Survivors
The overall objectives of this study are to better understand fertility decisions made by young women with breast cancer, describe the outcomes for women who attempt egg/embryo freezing and identify factors that influence decisions in order to better counsel and help our young breast cancer survivors in the future. This study will help us better understand the success rate of fertility preservation in women with breast cancer and how breast cancer survivors attempt to build a family after treatment. We will also explore decisions made by young women with breast cancer about delaying or interrupting endocrine therapy for pregnancy and family building.
Helena Furberg-Barnes, MSPH, PhD, Epidemiology-Biostatistics
Project Title: Body composition and the obesity paradox in renal cell carcinoma
Obesity is a risk factor for getting kidney cancer but patients with high BMI survive longer than those who have normal BMI. Reasons for this “obesity paradox” are unknown. In this study we are refining BMI into specific body composition variables (like muscle and amount of fat) and examining how patient body composition is associated with tumor features, survival and tumor genomics.
Andrea Barrio, MD, FACS, Department of Surgery
Project Title: A Prospective Surveillance Program for Assessment and Treatment of Breast Cancer-Related Lymphedema after Axillary Lymph Node Dissection
This study will prospectively determine the incidence of upper extremity lymphedema after axillary lymph node dissection using rigorous measurement protocols. We will also evaluate the role of inflammatory biomarkers, as well as traditional patient and treatment factors, in the pathogenesis of lymphedema. Finally we will investigate the association between patient-reported symptoms of lymphedema and measured lymphedema to define an optimal threshold for intervention.
Elizabeth Comen, MD, Department of Medicine
Project Title: CYP2D6 phenotype, tamoxifen treatment and risk of contralateral breast cancer in the WECARE study population
The objective of this study is to fully characterize the CYP2D6 phenotype and determine its impact on the association between tamoxifen and risk of CBC in the WECARE study population. This will provide crucial clinical information and a significant step toward developing personalized breast cancer treatment and surveillance strategies geared toward reducing the incidence of CBC.
Anthony F. Yu, MD, Cardiology Service, Department of Medicine
Project Title: A Phase 2 Trial of Carvedilol for the Prevention of Trastuzumab Induced Cardiac Dysfunction among Women with HER2-Positive Breast Cancer Using Myocardial Strain Imaging for Early Risk Stratification
This intervention trial is designed to investigate the effectiveness of carvedilol therapy at preventing the development of cardiotoxicity in breast cancer patients treated with trastuzumab who are identified as being at risk because of subclinical LV dysfunction by 2D speckle tracking, a novel echocardiographic modality.
Danielle Novetsky Friedman, MD, Department of Pediatrics
Project Title: Assessing Insulin Sensitivity and Diabetes Mellitus Risk in Neuroblastoma Survivors Treated with Abdominal Irradiation: A Pilot Study
This pilot study uses a single-institutional cohort of neuroblastoma survivors to ascertain mechanisms leading to diabetes mellitus in this high-risk population.
Darren R. Feldman, MD, Genitourinary Oncology Service, Department of Medicine
Project Title: Investigation into the Mechanism of Cisplatin-Induced Cardiovascular Toxicity: A Study of Acute Changes in Endothelial Function Following Cisplatin-Based Chemotherapy in Men with Germ Cell Tumors (GCT)
This is a pilot longitudinal study testing changes in endothelial function among male germ cell tumor patients treated with cisplatin-based chemotherapy or surgery alone.
Shrujal S. Baxi, MD, MPH, Head and Neck Oncology Service, Department of Medicine
Project Title: Competing Causes of Mortality in Survivors of Head and Neck Squamous Cell Carcinoma
This study assesses long-term mortality rates and identifies predisposing risk factors for competing causes of mortality in survivors of head and neck squamous cell carcinoma.
Victoria Blinder, MD, MSc, Breast Cancer Medicine Service, Department of Medicine
Project Title: Ethnic Differences in the Impact of Breast Cancer on Employment Status, Financial Situation, and Quality of Life
This matched cohort study aims to identify and describe ethnic differences in employment status, financial situation, and quality of life after treatment for breast cancer, with the ultimate goal of developing interventions that may significantly improve the lives of breast cancer survivors.
Elizabeth Ryan, PhD, Department of Psychiatry & Behavioral Sciences
Project Title: Rehabilitation of Chemobrain in Breast Cancer Survivors
This study will investigate whether breast cancer survivors with demonstrated cognitive difficulties who have received chemotherapy can improve cognitive side effects through use of a five-week rehabilitation software training program.
Tim Ahles, PhD, Department of Psychiatry & Behavioral Sciences
Project Title: Chemotherapy-Induced Cognitive Change and Deoxyribonucleic Acid (DNA) Damage in Breast Cancer Survivors
The primary objective of this project is to obtain preliminary data regarding the association between DNA damage associated with chemotherapy and cognitive dysfunction in breast cancer survivors.
Kevin Oeffinger, MD, Department of Pediatrics
Project Title: Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Leukemia Following Total Body Irradiation and Stem Cell Transplant
The long-term objective of the study is to reduce risk and prevent the development of insulin resistance, glucose intolerance, diabetes mellitus, dyslipidemia, metabolic syndrome, and premature cardiovascular disease in women who were treated with total body irradiation (TBI) followed by an allogeneic or autologous stem cell transplant. If the amount of visceral adipose tissue is increased in women who were treated with TBI, and if this outcome is associated with insulin resistance and dyslipidemia (as it in the general population), then targeted interventions will be designed to reduce that risk.
David Weinstock, MD, Bone Marrow Transplant Service, Infectious Diseases Service, Department of Medicine
Project Title: Assaying Risk for Secondary Leukemia Among Women Treated for Breast Cancer
This study proposes to evaluate a subset of women who develop acute myelogenous leukemia/myelodysplastic syndrome (t-AML) after treatment for breast cancer to determine if they have identifiable defects in double-strand break repair that confer an increased predisposition to leukemogenesis. t-AML is believed to result from the misrepair of DNA double-strand breaks introduced by clastogenic chemotherapy and radiation.
Population Sciences Research Program
The Population Sciences Research Program (PSRP) is designed to stimulate interdisciplinary research in population science. Population science research can impact public health in general terms. Cancer-related topics can include research on prevention strategies, risk factors, and causes. Other studies may focus on cancer care, the well-being of individuals after a cancer diagnosis, and cancer health policy.
Every year, the PSRP supports population science research at MSK through a National Cancer Institute core grant. The PSRP backs projects co-lead by a population scientist and an expert in a complementary discipline. Prior awardees include:
Project Title: Association between Clonal Hematopoiesis of Indeterminate Potential and Cardiotoxicity in Early-Stage Breast Cancer
Project Title: Evaluating Experiences of BRCA 1/2 Mutation Carriers Identified through a Novel Population-Based Genetic Testing Model
Project Title: Integrating SNPs and Biomarkers for Screening Healthy Men for Risk of Dying from Prostate Cancer
Project Title: Defining Supportive Care Needs of Patients with Erdheim-Chester Disease and their Caregivers
Talia Zaider, PhD and Ann Marie Mazzella Ebstein, PhD, RN
Project Title: Advancing Family-Centered Care Nursing Practices in Inpatient Oncology
Project title: Geriatrics communication skills-training program for oncology clinicians to improve management of care for geriatric cancer patients
Project title: Longitudinal neurocognitive and neuroimaging outcomes in older patients with multiple myeloma treated with autologous stem cell transplantation
Project title: Exercise regulation of intestinal stem cell biology and function
Emily Tonorezos, MD, MPH, and Eric Pamer, MD
Project title: A phase II study of overnight fasting after treatment (ONFat)
Helena Furberg Barnes, MSPH, PhD, and Andrew Dannenberg, MD
Project title: Metabo-inflammation and the obesity paradox in kidney cancer
Project title: Assessment of cognitive dysfunction in TKI-treated chronic myelogenous leukemia patients using cognitive-experimental methods
Project title: Decision-making and psychological outcomes in low risk papillary thyroid cancer
Project title: Development of an intervention to help low-income breast cancer patients work during treatment
Jennifer Hay, PhD and Irene Orlow, PhD
Project title: Personalized genomic testing for melanoma: maximizing comprehension and health outcomes in skin cancer patients
Project title: Streamlining the delivery of genetic testing in the ovarian cancer context: a pilot study of patient outcomes
Jason Huse, MD, PhD; Sara Olson, PhD; and Robert Young, MD
Project title: Evaluating the etiological and clinical factors distinguishing molecular subclasses of diffuse glioma: a pilot study
Thomas Atkinson, PhD, and Pamela Ginex, EdD, MPH, RN, OCN
Project title: Using a patient-centered mHealth intervention to improve adherence to oral anticancer medications
Project title: Development and refinement of a bereavement risk-screening tool
Project title: Aerobic training modulation of metastatic biology using a transparent zebrafish model
Project title: IFACT — incidental findings in advanced cancer therapy
Project title: Histopathologic characteristics of MRI background parenchymal enhancement as a biomarker of breast cancer risk
Project title: Aging-related genes, cognitive functions, and amyloid imaging in brain tumor patients.
Project title: Determining the biologic basis for differences seen in patients with colorectal cancer in West Africa compared to the US.
Project title: Diagnosis-related errors in cancer: feasibility study
Project title: RTEL1 and idiopathic bone marrow failure